Table 4.

Culex P450s associated with insecticide resistance. P450s in bold have been heterologously expressed and validated as pyrethroid metabolizers.

P450specieslocationinsecticidereference
CYP6M10C. quinquifasciatusUSA (Huntsville HamCq strain); Saudi Arabia (ISOP450 strain); Japan (ISOJPAL strain)Permethrin, Deltamethrin[26,57,58,86133]
CYP4H34C. quinquifasciatusSaudi Arabia (ISOP450 strain); Japan (ISOJPAL strain)Permethrin[86,87,89]
CYP6AA7C. quinquifasciatusUSA (Huntsville and Mobile, HAmCq and MAmCq strains respectively)Permethrin[133,134]
CYP4C5W1C. quinquifasciatusUSA (Huntsville and Mobile, HAmCq and MAmCq strains respectively)Permethrin[133,134]
CYP9J40C. quinquifasciatusUSA (Huntsville HamCq strain)Permethrin[133]
CYP9J34C. quinquifasciatusUSA (Huntsville HamCq strain)Permethrin[133]
CYP6F1C. pipiensChina (Shanghai Insect Institute strain)Deltamethrin[135]
CYP4H21C. pipiensChina (Shanghai Insect Institute strain)Deltamethrin[136]
CYP4H22v1C. pipiensChina (Shanghai Insect Institute strain)Deltamethrin[136]
CYP4J4v2C. pipiensChina (Shanghai Insect Institute strain)Deltamethrin[136]
CYP4J6v1C. pipiensChina (Shanghai Insect Institute strain)Deltamethrin[136]
CYP4J6v2C. pipiensChina (Shanghai Insect Institute strain)Deltamethrin[136]