Issue compiled and edited by Anusha Mishra, Zebulun Kurth-Nelson, Catherine Hall and Clare Howarth
Cognitive neuroscientists depend on the use of non-invasive blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) to study brain function in humans. Although commonly used as a surrogate measure of brain activity, BOLD signals largely reflect changes in blood flow. Correctly understanding the mechanisms that link brain function to blood flow is, therefore, critical when interpreting BOLD. This theme issue brings together scientists who use BOLD as a tool and scientists who study the mechanisms that underlie BOLD signals to show how the findings from cellular neuroscience can help to advance our understanding of this relationship in different brain regions, conditions or diseases, and to discuss the implementation of advanced technologies and the development of new analysis methods in cognitive neuroscience that have enhanced what we can learn from BOLD about brain function.
This issue is based on a Theo Murphy international scientific meeting which was held in January 2016.
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