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Molecular mechanism of pore formation by aerolysin-like proteins

Marjetka Podobnik, Matic Kisovec, Gregor Anderluh
Published 19 June 2017.DOI: 10.1098/rstb.2016.0209
Marjetka Podobnik
Department of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, 1000 Ljubljana, Slovenia
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  • For correspondence: marjetka.podobnik@ki.si
Matic Kisovec
Department of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, 1000 Ljubljana, Slovenia
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Gregor Anderluh
Department of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, 1000 Ljubljana, Slovenia
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Abstract

Aerolysin-like pore-forming proteins are an important family of proteins able to efficiently damage membranes of target cells by forming transmembrane pores. They are characterized by a unique domain organization and mechanism of action that involves extensive conformational rearrangements. Although structures of soluble forms of many different members of this family are well understood, the structures of pores and their mechanism of assembly have been described only recently. The pores are characterized by well-defined β-barrels, which are devoid of any vestibular regions commonly found in other protein pores. Many members of this family are bacterial toxins; therefore, structural details of their transmembrane pores, as well as the mechanism of pore formation, are an important base for future drug design. Stability of pores and other properties, such as specificity for some cell surface molecules, make this family of proteins a useful set of molecular tools for molecular recognition and sensing in cell biology.

This article is part of the themed issue ‘Membrane pores: from structure and assembly, to medicine and technology’.

Footnotes

  • One contribution of 17 to a discussion meeting issue ‘Membrane pores: from structure and assembly, to medicine and technology’.

  • Accepted October 14, 2016.
  • © 2017 The Author(s)
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5 August 2017
Volume 372, issue 1726
Philosophical Transactions of the Royal Society B: Biological Sciences: 372 (1726)
  • Table of Contents
Discussion meeting issue ‘Membrane pores: from structure and assembly, to medicine and technology’ organized and edited by Robert Gilbert, Hagan Bayley and Gregor Anderluh

Keywords

aerolysin
lysenin
monalysin
pore-forming protein
membranes
pore formation
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Molecular mechanism of pore formation by aerolysin-like proteins
Marjetka Podobnik, Matic Kisovec, Gregor Anderluh
Phil. Trans. R. Soc. B 2017 372 20160209; DOI: 10.1098/rstb.2016.0209. Published 19 June 2017
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Review article:

Molecular mechanism of pore formation by aerolysin-like proteins

Marjetka Podobnik, Matic Kisovec, Gregor Anderluh
Phil. Trans. R. Soc. B 2017 372 20160209; DOI: 10.1098/rstb.2016.0209. Published 19 June 2017

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  • Article
    • Abstract
    • 1. Introduction
    • 2. Aerolysin-like β-pore-forming proteins
    • 3. Structural features of aβ-pore-forming proteins
    • 4. Structures of pores and mechanism of pore formation
    • 5. Concluding remarks
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