It has become widely accepted that homeostatic and Hebbian plasticity mechanisms work hand in glove to refine neural circuit function. Nonetheless, our understanding of how these fundamentally distinct forms of plasticity compliment (and under some circumstances interfere with) each other remains rudimentary. Here, I describe some of the recent progress of the field, as well as some of the deep puzzles that remain. These include unravelling the spatial and temporal scales of different homeostatic and Hebbian mechanisms, determining which aspects of network function are under homeostatic control, and understanding when and how homeostatic and Hebbian mechanisms must be segregated within neural circuits to prevent interference.
This article is part of the themed issue ‘Integrating Hebbian and homeostatic plasticity’.
One contribution of 16 to a discussion meeting issue ‘Integrating Hebbian and homeostatic plasticity’.
- Accepted July 7, 2016.
- © 2017 The Author(s)
Published by the Royal Society. All rights reserved.