Shhh! Silencing by microRNA-155

Grace Teng, F. Nina Papavasiliou

Abstract

Small RNAs mediate a diverse pot-pourri of post-transcriptional silencing mechanisms, ranging from ‘classical’ RNA interference (RNAi), to gene repression by microRNAs (miRNAs), to maintenance of genomic stability by repeat-associated small RNAs. Here, we review recent findings on the function of miR-155, particularly its roles in mammalian innate and adaptive immunity, viral infection and oncogenesis.

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Footnotes

  • One contribution of 17 to a Discussion Meeting Issue ‘DNA deamination in immunity, virology and cancer’.

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