Skip to main content
  • Other Publications
    • Philosophical Transactions B
    • Proceedings B
    • Biology Letters
    • Open Biology
    • Philosophical Transactions A
    • Proceedings A
    • Royal Society Open Science
    • Interface
    • Interface Focus
    • Notes and Records
    • Biographical Memoirs

Advanced

  • Home
  • Content
    • Latest issue
    • Forthcoming
    • All content
    • Subject collections
    • Videos
  • Information for
    • Authors
    • Guest editors
    • Reviewers
    • Readers
    • Institutions
  • About us
    • About the journal
    • Editorial board
    • Policies
    • Citation metrics
    • Open access
  • Sign up
    • Subscribe
    • eTOC alerts
    • Keyword alerts
    • RSS feeds
    • Newsletters
    • Request a free trial
  • Propose an issue
You have accessRestricted access

GTPases: a family of molecular switches and clocks

Henry R. Bourne
Published 29 September 1995.DOI: 10.1098/rstb.1995.0114
Henry R. Bourne
Departments of Pharmacology and Medicine and the Cardiovascular Research Institute, University of California, San Francisco, California 94143, U. S. A.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Members of the GTPase superfamily share a core domain with a conserved three-dimensional structure and a common GTPase cycle, but perform a wide variety of regulatory tasks in eukaryotic cells. Evolution has created functional diversity from the conserved GTPase structure in two principal ways: (i) by combining in the product of a single gene the core GTPase domain attached to one or more additional folded domains; (ii) by building around a core GTPase an assembly of proteins encoded by different genes. Analysis of the patterns of conserved amino acid side chains on surfaces of Ga proteins reveals interfaces with other proteins in the G-protein signal linking device.

Footnotes

  • This text was harvested from a scanned image of the original document using optical character recognition (OCR) software. As such, it may contain errors. Please contact the Royal Society if you find an error you would like to see corrected. Mathematical notations produced through Infty OCR.

  • Scanned images copyright © 2017, Royal Society

Royal Society Login

Sign in for Fellows of the Royal Society

Fellows: please access the online journals via the Fellows’ Room

Not a subscriber? Request a free trial

Log in using your username and password

Enter your Philosophical Transactions of the Royal Society B: Biological Sciences username.
Enter the password that accompanies your username.
Forgot your user name or password?

Log in through your institution

You may be able to gain access using your login credentials for your institution. Contact your library if you do not have a username and password.

Pay Per Article - You may access this article or this issue (from the computer you are currently using) for 30 days.

Regain Access - You can regain access to a recent Pay per Article or Pay per Issue purchase if your access period has not yet expired.

PreviousNext
Back to top
PreviousNext
29 September 1995
Volume 349, issue 1329
  • Table of Contents
Share
GTPases: a family of molecular switches and clocks
Henry R. Bourne
Phil. Trans. R. Soc. Lond. B 1995 349 283-289; DOI: 10.1098/rstb.1995.0114. Published 29 September 1995
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Email

Thank you for your interest in spreading the word on Philosophical Transactions of the Royal Society B: Biological Sciences.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
GTPases: a family of molecular switches and clocks
(Your Name) has sent you a message from Philosophical Transactions of the Royal Society B: Biological Sciences
(Your Name) thought you would like to see the Philosophical Transactions of the Royal Society B: Biological Sciences web site.
Print
Manage alerts

Please log in to add an alert for this article.

Sign In to Email Alerts with your Email Address
Citation tools

GTPases: a family of molecular switches and clocks

Henry R. Bourne
Phil. Trans. R. Soc. Lond. B 1995 349 283-289; DOI: 10.1098/rstb.1995.0114. Published 29 September 1995

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Article reuse

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related articles

Cited by

Print issues available for purchase

Open biology

  • PHILOSOPHICAL TRANSACTIONS B
    • About this journal
    • Contact information
    • Purchasing information
    • Propose an issue
    • Open access membership
    • Recommend to your library
    • FAQ
    • Help

Royal society publishing

  • ROYAL SOCIETY PUBLISHING
    • Our journals
    • Open access
    • Publishing policies
    • Conferences
    • Podcasts
    • News
    • Blog
    • Manage your account
    • Terms & conditions
    • Cookies

The royal society

  • THE ROYAL SOCIETY
    • About us
    • Contact us
    • Fellows
    • Events
    • Grants, schemes & awards
    • Topics & policy
    • Collections
    • Venue hire
1471-2970

Copyright © 2018 The Royal Society