The microbial formation of methane from organic compounds greater than C$_2$ in chain length demands a mixture of methanogenic and chemoheterotrophic non-methanogenic bacteria. The chemoheterotrophic, non-methanogens initiate the reactions by well established pathways, hydrolysing complex polymers and fermenting the unit constituents to smaller end-product molecules, which are further metabolized by other chemoheterotrophs to acetic acid, H$_2$ and CO$_2$. The methanogens are essential physiological partners in the overall conversion of the initial substrates to this level because they oxidize H$_2$ and reduce CO$_2$ to form methane. The ultimate formation of acetate as the chief intermediate in this fermentation depends on the removal of H$_2$ by the methanogens. Otherwise, these acetogenic reactions are not thermodynamically feasible. Acetate, the major precursor of CH$_4$ in fermentation systems, is converted to CH$_4$ and CO$_2$ via a unique aceticlastic reaction. Examples of microbial partnerships producing methane from the fermentation of organic compounds are described.